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Dr. Harvey Bartnof is the founder of the California Longevity & Vitality Medical Institute. -- Testosterone is naturally produced primarily through a man's testes. -- The hormone helps regulate bone density, fat distribution, muscle strength, red blood cell production, sex drive and sperm production,

Read more …Longevity, anti-aging specialists simply refer to it as "T." - CNN iReport (article link)

UCSF scientists are reporting several studies showing that psychological stress leads to shorter telomeres – the protective caps on the ends of chromosomes that are a measure of cell age and, thus, health. The findings also suggest that exercise may prevent this damage.

Read more …Exercise may prevent stress on telomeres, a measure of cell health - EurekAlert! (article link)

(University of California - San Diego) Researchers at the University of California, San Diego School of Medicine, the Gladstone Institutes in San Francisco and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing, primitive neural precursor cells from human embryonic stem cells (hESCs) that can be directed to become many types of neuron without increased risk of tumor formation.

Read more …Scientists create stable, self-renewing neural stem cells - EurekAlert! (article link)

Researchers found that two copies of the protein bind together to form what is called a "dimer," and how that dimer physically interacts with DNA, regulating how enzymes called telomerases access and lengthen the telomeres.

- "Cdc13 has a crucial support role in maintaining and lengthening telomeres," -- "..telomere lengthening is one of the ways cancer cells obtain their immortality."
- they are investigating the potential of small molecule inhibitors to serve as viable therapeutics against cancer by blocking telomerase and their related proteins.
- When the researchers introduced mutations into Cdc13 that prevented the protein from forming a dimer, it caused the telomeres to shorten, which would hasten the demise of the yeast cells.
- When they created mutations that prevented Cdc13 dimers from binding to DNA, it had the effect of excessively lengthening telomeres, an act the researchers attribute to the notion that Cdc13 helps regulate the ability of DNA-replication enzymes to access telomeres.

Read more …Protein Cdc13 has crucial role in maintaining and lengthening telomeres, links to preventing aging...

The number of times our cells can divide is dictated by telomeres, stretches of DNA at the tips of our chromosomes.

The act of preserving telomeres through telomerase is a hallmark of only certain cells, particularly those in developing embryos. In adults, telomerase is active in stem cells, certain immune system cells and, most notably, cancer cells. Understanding how telomeres keep our chromosomes – and by extension, our genomes – intact is an area of intense scientific focus in the fields of both aging and cancer.

"We know that disabling this protein in humans will most likely lead to senescence, which is of particular interest in cancer, because telomere lengthening is one of the ways cancer cells obtain their immortality."

Read more …Q. What are Telomeres and what is the link with treating aging as a disease and cancer - (question)

- The researchers used a type of embryonic rat stem cells known as mesenchymal stem cells (MSCs) to restore ovary function in experimental rats.
- Within two weeks, the rats who had been treated with stem cells had regained full ovarian function and after eight weeks their hormone levels were the same as the rats who did not have ovarian failure.

"This is proof of concept, and there is still a long way to go before we can apply this to women," -- "Nevertheless, this work holds out the possibility that women with premature ovarian failure might be able to bear a baby of their own." -- "What we have done is proven that we can restore apparently fully-functioning ovaries in rats. The next step is to look how these rats might reproduce,"

Read more …Injecting a particular type of Stem Cells into infertile female rats can restore the function of...

The first randomized, placebo-controlled U.S. clinical trial to assess the use of bone marrow-derived mononuclear cells (BMC) in patients after a ST-elevation myocardial infarction (STEMI; severe heart attack) demonstrated a strong safety profile for this cell therapy, based on phase 1 results published in the September issue of the American Heart Journal.

- "The use of adult stem cells, derived from the patient's own bone marrow, presents a potential new type of therapy to benefit individuals after they suffer a heart attack,"
- "Also, these types of stem cells do not possess any of the ethical concerns of embryonic stem cell research."

Read more …First US trial of bone-marrow Stem Cells for heart attack patients proves safe - EurekaAlert!...

Your body's pH, which stands for potential of hydrogen, plays a huge role in the proper functioning of cells and organs. Measured on a scale ranging from 0 to 14, a healthy pH helps to regulate normal cell production and healthy tissue throughout your body. Seven on the scale is considered to be neutral, with anything above that being alkaline pH (or basic) and anything below that being acidic. Normal body pH should be slightly alkaline at around 7.35, so when levels drop below 7 and dip into acidic pH, there begins to be a problem.

When you have an acidic pH reading, your body tries to return to a normal level of alkalinity. In order to get the base it needs, the body may "borrow" minerals and nutrients such as calcium and magnesium from bones, thereby weakening those bones. Acidic pH is believed to cause other issues such as:

- Fatigue and illness, Decreased cell energy, Low bone density, Stunted repair of cell damage, Limited ability of the body to destroy heavy metals, Hinder the ability to absorb important nutrients

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