Researchers discovered that the DNA damage detector PARP-1 plays a key role in the activation of transcription factor NF-kappaB. Years ago they were able to show that NF-kappaB plays a key role in tumor cell survival.
- The regulator of gene expression transcription factor NF-kappaB triggers a survival program, which blocks programmed cell death and opposes p53, p53 has a key function in the activation of programmed cell death called apoptosis.
- PARP-1 recognizes sites of DNA damage within seconds and then attracts several proteins to form a complex in the cell nucleus.
- "We have thus identified the start signal for NF-kappaB activation" -- "the hope to identify targets for the development of drugs, which allow to switch off the survival factor NF-kappaB in cancer diseases."
How cells tolerate DNA damage -- start signal for cell survival program identified