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Mon, Jul

Researchers solve a crucial piece of the DNA repair response puzzle; A protein named CtIP plays an essential role in the DNA damage "signal-to-repair" process - EurekAlert! (article link)

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The researchers depleted CtIP from human cells and caused DNA damage. Without the CtIP, they discovered, the cells could no longer trim back the damaged DNA strands, which brought the whole repair process to an abrupt halt.
- "CtIP is another important player in the double-strand break response," says Hunter. "We have added another piece to the complex puzzle of DNA repair."
- Some studies have estimated that the DNA in a single human cell gets damaged over 10,000 times every day.
- If not repaired properly, the damage leads to mutations, which over time can cause cancer.

Mobilizing the repair squad: Critical protein helps mend damaged DNA
http://www.eurekalert.org/pub_releases/2009-12/si-mtr121709.php