Sat, May

"For people with life-threatening blood cancers like leukemia and lymphoma or other diseases, a cure exists. Be The Match® connects patients with their donor match for a life-saving marrow or umbilical cord blood transplant."

Why I donated my bone marrow - CNN (article link), How you can use Facebook to help this leukemia patient find his missing donor - Yahoo (article link)

Read more …New Year's 2013 Resolution, Save A Life This Year - BeTheMatch (website link)

A single shot could be one of the biggest advances in cancer research in decades, scientists say. But the research almost didn't happen

In the research published Wednesday, doctors at the University of Pennsylvania say the treatment made the most common type of leukemia completely disappear in two of the patients and reduced it by 70 percent in the third.

Read more …New leukemia treatment exceeds 'wildest expectations' - MSNBC News (article link)

(Cincinnati Children's Hospital Medical Center) Scientists have used a genetically re-engineered herpes virus that selectively hunts down and infects cancerous tumors and then delivers genetic material that prompts cancers to secrete a biomarker and reveal their presence. According to a study appearing May 11 in PLoS (Public Library of Science) ONE, the novel technology has the potential to vastly improve cancer diagnosis by allowing the disease to be caught at much earlier stages and to monitor the effectiveness of therapy.

"The researchers engineered a herpes simplex virus mutant they called rQ-M38G, reprogramming its genetic makeup so it bypasses healthy tissues and instead targets rapidly dividing cancer cells for infection. They also genetically armed the virus so it prompts cancer cells to secrete Gaussia luciferase (GLuc)."

"GLuc is a luminescent, easily detectable protein the researchers used as a universal blood biomarker for cancer cells infected by rQ-M38G. Because rQ-M38G/GLuc might also help shrink cancer, it is part of a new class of agents dubbed "theragnostics" that can simultaneously be used for diagnosis and therapy, Dr. Cripe said."

Read more …Scientists use genetically altered virus to get tumors to tattle on themselves - EurekAlert...

(Virginia Commonwealth University) Cancer researchers are a step closer to finding a cure for advanced prostate cancer after effectively combining an anti-cancer drug with a viral gene therapy in vivo using novel ultrasound-targeted microbubble-destruction (UTMD) technology.

"UTMD uses microscopic, gas-filled bubbles that provide great contrast against soft tissue when viewed using ultrasound equipment. The microbubbles can also be paired with complexes made to bind to specific areas of the body, allowing them to be targeted. In this study, a weakened adenovirus (a virus that is typically associated with respiratory infections) engineered to deliver the tumor-suppressing gene mda-7/IL-24 was joined to the microbubbles and delivered through the blood stream directly into the prostate. UTMD's ability to systematically target a disease site could revolutionize gene therapy."

"Although our studies focused on prostate cancer, in principle, they could be applied to many other cancers," says Fisher. "Additionally, ultrasound-targeted microbubble destruction could deliver directly to cancers other viruses, therapeutic genes not contained in a virus and potentially other therapeutic proteins."

Read more …Microbubble-delivered combination therapy eradicates prostate cancer in vivo - EurekAlert (article...

(University of California - Los Angeles Health Sciences) Researchers with UCLA's Jonsson Comprehensive Cancer Center have discovered a way to amp up the power of killer T-cells, called CD8 cells, making them more functional for longer periods of time and boosting their ability to multiply and expand within the body to fight melanoma, a new study has found.

"The study, done in mouse models of metastatic melanoma that had spread to the brain, has important clinical implications, as the method could boost the cancer-killing power of experimental immunotherapies being tested now in various cancers, including deadly glioblastoma and metastatic melanoma, both of which are very difficult to treat successfully."

"The process Prins and his team used sought to mimic the way the T cells in the immune system recognize and fight viruses in the body, stimulating what is called the innate immune system. The innate immune system is comprised of cells that immediately defend the body from infection and frequently is not stimulated in the presence of cancer, Prins said. However, the innate immune cells can be tricked into thinking a virus is present by treating with compounds that activate Toll-like receptors (TLR)."

Read more …UCLA scientists discover way to amp up power of killer T cells - EurekAlert (article link)

(University of Michigan Health System) A primary reason that head and neck cancer treatments fail is the tumor cells become resistant to chemotherapy drugs. Now, researchers at the University of Michigan Comprehensive Cancer Center have found that a compound derived from the Indian spice curcumin can help cells overcome that resistance.

Read more …Curcumin compound improves effectiveness of head and neck cancer treatment, U-M study finds -...

(Digestive Disease Week) Oncolytic viruses quickly infect and kill cancer stem cells, which may provide a treatment for tumors that are resistant to conventional chemotherapy and radiation, particularly pancreatic cancer, according to new research from Memorial Sloan-Kettering Cancer Center in New York. The findings are especially important since pancreatic cancer has a poor prognosis and is difficult to detect and treat at early stages.

"Investigators sought to determine whether the viruses containing a marker gene that expresses green fluorescent protein could infect pancreatic cancer stem cells and ultimately kill the cancer stem cell. Their findings were promising and documented that viral activity was correlated with green fluorescent protein expression."

Read more …Oncolytic viruses effectively target and kill pancreatic cancer stem cells - EurekAlert (article...

(University of Missouri-Columbia) In a new study, a University of Missouri researcher has found that a compound in parsley and other plant products, including fruits and nuts, can stop certain breast cancer tumor cells from multiplying and growing.

Read more …[Angiogenesis] Parsley, celery carry crucial component for fight against breast cancer, MU...

Immunotherapy used in proof-of-principle treatment for Wiskott-Aldrich Syndrome at the Children's Hospital of Philadelphia

In a novel approach that works around the gene defect in Wiskott-Aldrich syndrome, an inherited immune deficiency disorder, researchers used an alternative cell signaling pathway to significantly improve immune function in a 13-year-old boy with the disease. The study, at The Children's Hospital of Philadelphia, provides a proof-of-principle that immunotherapy, which harnesses elements of the body's immune system, may be used to treat this rare but often deadly disorder.

Read more …Novel therapy improves immune function in teen with rare disease - EurekAlert! (article link)

(University of Alberta Faculty of Medicine & Dentistry) Researchers in the Faculty of Medicine & Dentistry at the University of Alberta have made an important discovery that provides a new understanding of how our immune system "learns" not to attack our own body, and this could affect the way doctors treat patients with autoimmune diseases and cancer.

Read more …Discovery could change the way doctors treat patients with cancer and autoimmune diseases -...

(Dana-Farber Cancer Institute) Dana-Farber Cancer Institute scientists have discovered new details of how cancer cells escape from tumor suppression mechanisms that normally prevent these damaged cells from multiplying. They also demonstrated a potential link between this cell proliferation control mechanism and the cognitive deficits caused by Down syndrome.

Read more …Researchers identify key players in cancer cells' survival kit - EurekAlert! (article link)

(Duke University Medical Center) A major discovery about an enzyme's structure has opened a window on understanding DNA repair. Scientists at Duke University Medical Center have determined the structure of a nuclease that will help scientists to understand several DNA repair pathways, a welcome development for cancer research.


Read more …Nature's elegant solution to repairing DNA in cancer, other conditions - EurekAlert! (article link)

1. Chicken and Broccoli
- Broccoli contains sulforaphane which helps prevent breast cancer; Chicken has selenium which does the same; Together they are 3 times more effective than taking them alone.
2. Avocado and Salsa
- The fat in the avocado helps you absorb up to 5 times more lecopene from the salsa.
3. Yellow Onions and Turmeric
- Helps prevent pre-cancerous colon polyps.
4. Watercress and Salmon
- Watercress helps prevent cancer and salmon omega 3, they do the exact same thing, it decreases the rate of leukemia and kidney cancer.

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