Thu, Feb

Dr. Harvey Bartnof is the founder of the California Longevity & Vitality Medical Institute. -- Testosterone is naturally produced primarily through a man's testes. -- The hormone helps regulate bone density, fat distribution, muscle strength, red blood cell production, sex drive and sperm production,

Read more …Longevity, anti-aging specialists simply refer to it as "T." - CNN iReport (article link)

UCSF scientists are reporting several studies showing that psychological stress leads to shorter telomeres – the protective caps on the ends of chromosomes that are a measure of cell age and, thus, health. The findings also suggest that exercise may prevent this damage.

Read more …Exercise may prevent stress on telomeres, a measure of cell health - EurekAlert! (article link)

(University of California - San Diego) Researchers at the University of California, San Diego School of Medicine, the Gladstone Institutes in San Francisco and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing, primitive neural precursor cells from human embryonic stem cells (hESCs) that can be directed to become many types of neuron without increased risk of tumor formation.

Read more …Scientists create stable, self-renewing neural stem cells - EurekAlert! (article link)

Researchers found that two copies of the protein bind together to form what is called a "dimer," and how that dimer physically interacts with DNA, regulating how enzymes called telomerases access and lengthen the telomeres.

- "Cdc13 has a crucial support role in maintaining and lengthening telomeres," -- "..telomere lengthening is one of the ways cancer cells obtain their immortality."
- they are investigating the potential of small molecule inhibitors to serve as viable therapeutics against cancer by blocking telomerase and their related proteins.
- When the researchers introduced mutations into Cdc13 that prevented the protein from forming a dimer, it caused the telomeres to shorten, which would hasten the demise of the yeast cells.
- When they created mutations that prevented Cdc13 dimers from binding to DNA, it had the effect of excessively lengthening telomeres, an act the researchers attribute to the notion that Cdc13 helps regulate the ability of DNA-replication enzymes to access telomeres.

Read more …Protein Cdc13 has crucial role in maintaining and lengthening telomeres, links to preventing aging...

The number of times our cells can divide is dictated by telomeres, stretches of DNA at the tips of our chromosomes.

The act of preserving telomeres through telomerase is a hallmark of only certain cells, particularly those in developing embryos. In adults, telomerase is active in stem cells, certain immune system cells and, most notably, cancer cells. Understanding how telomeres keep our chromosomes – and by extension, our genomes – intact is an area of intense scientific focus in the fields of both aging and cancer.

"We know that disabling this protein in humans will most likely lead to senescence, which is of particular interest in cancer, because telomere lengthening is one of the ways cancer cells obtain their immortality."

Read more …Q. What are Telomeres and what is the link with treating aging as a disease and cancer - (question)

- The researchers used a type of embryonic rat stem cells known as mesenchymal stem cells (MSCs) to restore ovary function in experimental rats.
- Within two weeks, the rats who had been treated with stem cells had regained full ovarian function and after eight weeks their hormone levels were the same as the rats who did not have ovarian failure.

"This is proof of concept, and there is still a long way to go before we can apply this to women," -- "Nevertheless, this work holds out the possibility that women with premature ovarian failure might be able to bear a baby of their own." -- "What we have done is proven that we can restore apparently fully-functioning ovaries in rats. The next step is to look how these rats might reproduce,"

Read more …Injecting a particular type of Stem Cells into infertile female rats can restore the function of...

The first randomized, placebo-controlled U.S. clinical trial to assess the use of bone marrow-derived mononuclear cells (BMC) in patients after a ST-elevation myocardial infarction (STEMI; severe heart attack) demonstrated a strong safety profile for this cell therapy, based on phase 1 results published in the September issue of the American Heart Journal.

- "The use of adult stem cells, derived from the patient's own bone marrow, presents a potential new type of therapy to benefit individuals after they suffer a heart attack,"
- "Also, these types of stem cells do not possess any of the ethical concerns of embryonic stem cell research."

Read more …First US trial of bone-marrow Stem Cells for heart attack patients proves safe - EurekaAlert!...

Your body's pH, which stands for potential of hydrogen, plays a huge role in the proper functioning of cells and organs. Measured on a scale ranging from 0 to 14, a healthy pH helps to regulate normal cell production and healthy tissue throughout your body. Seven on the scale is considered to be neutral, with anything above that being alkaline pH (or basic) and anything below that being acidic. Normal body pH should be slightly alkaline at around 7.35, so when levels drop below 7 and dip into acidic pH, there begins to be a problem.

When you have an acidic pH reading, your body tries to return to a normal level of alkalinity. In order to get the base it needs, the body may "borrow" minerals and nutrients such as calcium and magnesium from bones, thereby weakening those bones. Acidic pH is believed to cause other issues such as:

- Fatigue and illness, Decreased cell energy, Low bone density, Stunted repair of cell damage, Limited ability of the body to destroy heavy metals, Hinder the ability to absorb important nutrients


(Reuters) - Pluristem Therapeutics said early clinical trials show its placenta-derived cell therapy is safe and improves quality of life in patients with peripheral artery disease, or PAD.

- Pluristem harvests cells from the placenta after a woman gives birth, so there is no ethical issue on using embryos.
- "We have proved we can use the placenta as a source for a product that doesn't require a match between the donor and patient,"

Pluristem's clinical trials showed patients experienced improvement in bloodstream, pain and quality of life for six months following a 20-minute session of injections.

Read more …Pluristem use the placenta as a source for stem cells, its therapy is promising for leg artery...

A team using StemCells Inc's nerve stem cells taken from aborted fetuses found that even a month after injury, the cells took up residence in the spine, proliferated and helped mice walk better.

- "These exciting results demonstrate an expanded window of opportunity for human neural stem cell intervention in spinal cord injury,"
- The cells migrated through the spine, grew and began to function -- 64% of the stem-cell-treated mice walked better, compared to 44% of mice treated with ordinary cells and 20% of placebo-treated mice.

About 1.25 million Americans have chronic spinal cord injuries. "This latest study provides additional evidence that the use of our human neural stem cells may be a viable treatment approach for them,".

Read more …Stem cells take up residence in mice with spine injury and help them walk better - Reuters...

The experts said they were particularly concerned about a firm in Germany called XCell-Center and about Beike, which offers stem cell treatments for a range of conditions including brain injury, cerebral palsy, multiple sclerosis, spinal cord injury and optic nerve damage.

- A spokesman for XCell said in a statement that its stem cell preparations are made from bone marrow and intended for "autologous" use, or use by patients from whom they came.
- Beike Biotech said in a statement that all its stem cells are administered by experienced physicians who work in and for leading hospitals in China.

Stem cells are standard treatments for leukemias and a few other genetic diseases, but their use in treating other conditions such as Parkinson's, spinal injury or optic nerve damage is as yet unproven.

Read more …Stem Cell therapy companies in China and Germany criticized by British experts warning of the...

"In an earlier study, we observed that middle-aged children of long-lived siblings have lower thyroid function compared to controls from the general population,"
"In the current study, we sought to assess whether in the generation of the long-lived siblings low thyroid function was related to enhanced survival of the parents of the siblings as well,"

After rating the longevity of these siblings' parents, the team analyzed the thyroid hormones in the siblings' blood. The two sets of values appeared to be strongly linked, supporting previous findings of heritability in decreased thyroid functioning and its relationship to long life.

Read more …Researchers link longevity with thyroid activity but other factors could be the cause - Reuters...

Chuck Murry, professor at the University of Washington, talks about his lab's research in regenerating new heart tissue out of stem cells.

- the building blocks of heart muscles, we can make the cells of blood vessels, connective tissue cells.
- progress in getting them to self assemble and organize a coherent tissue.
- we believe that by growing new heart muscle we can regress heart failure.
- we've shown that if we can transplant these in animals that have had a heart attack we can prevent them from developing heart failure.


Read more …Researcher talks about his lab's research in regenerating new heart tissue out of stem cells -...

Scientists in Romania say they have discovered a type of cell called telocites, which may be similar to stem cells.

- first found in the pancreases and then in 15 other organs.
- they hope that telocites can play a role in the regeneration and repair of the body because they are related to stem cells.

Read more …Scientists in Romania discover cell called telocites, which may help regenerate and repair the...

- Experts say it's time to recognize aging as a condition that can be treated and delayed.
- Because aging is not viewed as a disease scientists are hampered by regulators who license for diseases.
- By finding the genes thought to help determine longevity, scientists think they may be able to mimic their action to extend health span.

Read more …Specialists in aging are lobbying the FDA to consider redefining aging as a disease - Reuters...

- Scientists in Germany and Switzerland found that an enzyme called COX-2 triggers development of fat cells to become brown fat, instead of white fat.
- Once activated by cold temperatures, brown fat burns calories faster than regular fat.
- Mice who were genetically engineered to produce high levels of COX-2 burned energy faster and were protected from obesity.

Read more …Scientists now trying to use stem cells to generate brown fat cells to help speed up calorie burn....

- The findings suggest that women with Parkinson's could serve as their own stem cell donors.
- The endometrial stem cells generate less of an immune system rejection and women shed them naturally every month.
- The researchers transformed stem cells into dopamine-producing nerve cells like those in the brain.
- Parkinson's is caused by the destruction of brain cells that produce dopamine, an important message-carrying chemical involved in movement.

Read more …Stem cells from the lining of a woman's uterus transformed into brain cells in mice whose brains...

(HealthDay News) - Researchers at the U.S. National Institutes of Health have discovered bone-generating stem cells in the spine, at the end of the shins and in cartilage-rich areas of other bones.
- "Now researchers can explore ways to harness these cells so that ultimately they might be used to repair damaged or malformed bone."
- The U.S. National Institutes of Health has more about stem cells.

Read more …U.S. National Institutes of Health have discovered bone-generating Stem Cells in the spine - CBC...

- The differences in DAF-16 corresponded to differences in longevity, stress resistance and immunity between the four species, with higher levels of DAF-16 activity correlating to longer life, increased resistance and better immunity against some infections.

Read more …Scientists find specific gene DAF-16 is strongly linked to lifespan, immunity and disease...

Longevity and Premature Aging; the existence of the decades old practice of wearing a person down and trying to induce premature aging through high levels of stress and sleep deprivation has been denied by the medical community for decades, and so has psychological harassment.
- During a person’s sleep cycle the body goes into DNA repair mode so sleep deprivation can accelerate premature aging.
- It is the reverse of trying to stimulate the sirtuin genes for increased DNA repair and longevity.

Good large cholesterol is linked to inheritance but exercise increases and is linked to good cholesterol; diet is linked to reducing bad cholesterol. Calorie restriction which triggers the body’s survival mode response, stimulates the Sirtuin Genes, is linked to longevity but resveratrol also stimulates the Sirtuin Genes without the calorie restriction.
- Cholesterol; good large cholesterol has been linked to people living to 100 years old.
- Sirtuin Genes; kick in when the body is in survival mode and increase DNA repair and prevent cell death.
- Insulin; low levels are linked to longevity in research studies.

Clevers said the advantage offered by the "mother" stem cell finding would be that they could grow skin from its original basis -- allowing it to be "real new skin" with moisture from sebaceous glands and the ability to grow hair.
- "This is the mother of all the stem cells in the skin -- it makes all the other stem cells,"
- their discovery could dramatically improve skin treatments for victims of serious wounds and burns.
Read more …Stem Cells: Scientists find "mother" of all skin cells - Reuters (article link)

- You're the Life of the Party: Researchers speculate that their more resilient brains may be due to lower levels of cortisol--studies show that oversecretion of this "stress hormone" can inhibit brain cells' communication.
- You're a Flourisher: They have a positive outlook on life, a sense of purpose and community, and are healthier than "languishers"
- You Really Like Your Friends: "Good interpersonal relationships act as a buffer against stress," says Micah Sadigh, PhD

Chronic stress weakens the immune system and ages cells faster, ultimately shortening life span by 4 to 8 years, according to one study.

Read more … Secrets to Longevity: Surprising Signs You'll Live to 100 - Prevention (article link)