Work-related burnout can lead to inflammatory processes, which plays a key role in the initiation and progression of cardiovascular disease and other inflammatory-linked illness – Eureka Alert! (article link)

According to a new study from the Journal of Occupational and Health Psychology, published by the American Psychological Association (APA), women who experience job burnout and men who experience depression were found to have increased levels of two inflammation biomarkers – fibrinogen and C-reactive protein (CRP). Both of these biomarkers have been associated in numerous studies, with an increased risk of future cardiovascular disease and stroke, over and above the conventional risk factors like blood lipids and glucose.
- Blood levels of CRP and fibrinogen concentrations were used to measure levels of micro-inflammation.
- Fibrinogen is a blood-clotting factor that responds to vascular and tissue injury and CRP is a complex set of proteins produced when the body is dealing with a major infection or trauma.

Sexes differ in their immune reactions to burnout on the job and depression

Implications for stress management to prevent cardiovascular and other inflammation-related health problems

- These results suggest that the burned-out women and depressed men are at a greater risk for future inflammation-related diseases, like diabetes, heart disease and strokes compared with their non-burned out and non-depressed counterparts.

- Depression in the study is defined as a generalized distress encompassing all life domains.
- Burnout is defined as a depletion of an individual's energetic resources at work.
- Anxiety is defined as a person experiencing negatively-toned arousal.